Latanoprost 0.005% v/s Timolol Maleate 0.5% Pressure Lowering Effect in Primary Open Angle Glaucoma

Authors

  • Arshad Ali Lodhi, Khalid Iqbal Talpur, Mahtab Alam Khanzada

DOI:

https://doi.org/10.36351/pjo.v24i2.712

Abstract

Purpose: To compare the pressure lowering effect of Latanoprost 0.005% and Timolol Maleate 0.5% in the newly diagnosed patients of primary open angle glaucoma.

Material and Method: This open label, comparative study was conducted in the department of Ophthalmology, Liaquat University of Medical & Health Sciences Jamshoro / Hyderabad, from Jan 2006 to March 2006. 58 Patients (96 eyes) who qualified at the screening examination and meet the eligibility criteria were then assessed for best corrected visual acuity, base line IOP with applanation tonometery, angle grading with gonioscopy, anterior and posterior segment examination with slit lamp bimicroscopy.The patient’s base line cup / disc ratio and visual fields were also recorded for follow up assessment then the patients advised to instill latanoprost 0.005 % once daily in evening in eye that was randomly selected and timolol maleate 0.5 % twice daily in the contralateral eye of same patient to exclude all demographic systemic and ocular factors that may influence the IOP. Patients were followed on 1st week, 3rd week, 1.5 months, 2.0 months, 2.5 months and 3.0 months then compared the pressure lowering effects of both drugs.

Results: Out of 58 patients 30 (51.7%) were male and 28 (48.3%) were female and mean age was 60.5 years. During our study the base line IOP for timolol maleate was 25.8 mmHg and for latanoprost was 25.6 mmHg. During three months treatment the mean reduction in IOP was 6.55 mmHg (26.7%) timolol maleate and 7.41 mmHg (28.9%) in the patients receiving latanprost. The post-treatment IOP was 19.25 mmHg (P-value = 0.0001) in patients receiving timolol maleate and 18.18 mmHg (P-value 0.0001) in patients receiving latanoprost the difference between the values of reduction in IOP from base line IOP was 0.86 mmHg.

Conclusion: The IOP lowering effect of latanoprost was 2.2% greater than timolol maleate in newly diagnosed patients of primary open angle glaucoma.  

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Published

30-06-2008

How to Cite

1.
Mahtab Alam Khanzada AALKIT. Latanoprost 0.005% v/s Timolol Maleate 0.5% Pressure Lowering Effect in Primary Open Angle Glaucoma. pak J Ophthalmol [Internet]. 2008 Jun. 30 [cited 2024 Mar. 28];24(2). Available from: https://pjo.org.pk/index.php/pjo/article/view/712

Issue

Section

Review Articles