Serum Glycoproteins in Diabetic and Non-Diabetic Patients With and Without Cataract

Authors

  • Anjuman Gul Memon, Ata-ur-Rahman, Nessar Ahmed

DOI:

https://doi.org/10.36351/pjo.v24i3.694

Abstract

Purpose: To investigate the changes in serum glycoproteins from type 2 diabetic and non-diabetic patients with and without cataract.

Material and Method: A total of 85 subjects were selected for this study and divided into four groups. The first group consisted of 21 healthy subjects, the second group consisted of 21 diabetic patients with no chronic complications, the third group consisted of 20 diabetic patients with cataract and the fourth group had 23 non-diabetic patients with cataract. The patients with and without cataract were selected on clinical grounds from the Ziauddin University and Jinnah Postgraduate Medical Centre in Karachi, Pakistan.

Result: Diabetic patients with and without cataract had significantly higher levels of plasma glucose, glycated hemoglobin, glycated plasma proteins and serum fructosamine. In addition to these parameters, the levels of hexosamine, sialic acid and serum total protein were higher in diabetic compared to non diabetic subjects with and without cataract. Analysis of the protein fractions showed that alpha-1- and -2 golbulins were higher in diabetic patients without complications compared to healthy subjects. Serum alpha-1-globulin, alpha-2-globulin, beta globulins and gamma globulins were all significantly higher in diabetic patients with cataract compared to healthy subjects but not serum albumin.

Conclusion: The levels of serum glycoproteins in non-diabetic patients with cataract were not higher than those of healthy subjects thus mechanisms other than hyperglycaemia are responsible for the development of cataract in these patients.

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Published

30-09-2008

How to Cite

1.
Nessar Ahmed AGMA- ur-R. Serum Glycoproteins in Diabetic and Non-Diabetic Patients With and Without Cataract. pak J Ophthalmol [Internet]. 2008 Sep. 30 [cited 2024 Mar. 28];24(3). Available from: https://pjo.org.pk/index.php/pjo/article/view/694

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Section

Review Articles