Side Effects and Effectiveness of Subconjunctival Bevacizumab Injection in Patients with Corneal Neovascularization

Abstract

Purpose: To evaluate the side effects and effectiveness of subconjunctival bevacizumab injection in reducing corneal neovascularization.

Material and Methods: Patients selected according to inclusion and exclusion criteria were randomly allocated to either group 1 (patients were given subconjunctival bevacizumab injection) and group 2 (patients were given subconjunctival sham injection), its effectiveness in the form of decrease in neovascular area and side effects were compared between the two groups.

Results: 41 patients were included in each group. There was no statistical significance between the 2 groups in effectiveness of the subconjunctival injection as well as in the complications except decrease in the fibrinogen level which was observed in group 1.

Conclusion: Subconjunctival bevacizumab injection failed to show significant improvement in either corneal neovascularisation or visual acuity.