Evaluation of Fresh Human Amniotic Membrane Transplantation for the Treatment of Corneal Perforation and Impending Corneal Perforation
Purpose: To determine the outcome of amniotic membrane transplantation for the treatment of corneal perforation and impending corneal perforation.
Material and Methods: This Quasi experimental study was carried out in Ophthalmology department, Benazir Bhutto Hospital from 16th April 2007 to 15th April 2008. Total of 30 patients with either corneal perforation or impending corneal perforation were selected. Freshly prepared amniotic membrane was transplanted over these diseased corneas.
Results: Mean age was 58.7 years with minimum 28 years, maximum 75 years and standard deviation of ± 12.04, post op hospital stay was 1 week in 28 (93.3%) patients and 2 weeks in 2 (6.7%) patients with mean of 1.07 and standard deviation of ± 0.25, duration for which graft remained intact was minimum 1 week to maximum 10 weeks with mean of 3.97 weeks and standard deviation of ± 2.40. Patients were evaluated for relief of symptoms, reduction in conjunctival inflammation, epithelial healing and globe preservation. 28 patients (93.3%) showed improvement in symptoms, reduction in conjunctival inflammation, epithelial healing and globe preservation.
Conclusion: Amniotic membrane is a useful material in treating patients with corneal perforation and impending corneal perforation, by relieving the symptoms, healing the lesion, control of infection and ensuring globe preservation.