Mean Change in Intra-Ocular Pressure Following Trabeculectomy with Mitomycin C in Congenital Glaucoma

Abstract

Purpose: To determine the mean change in intraocular pressure after trabeculectomy with Mitomycin C surgery in primary congenital glaucoma.

Study Design: Quasi experimental study.

Place and Duration of Study: Outpatient department of Ophthalmology Hayatabad Medical Complex, Peshawar. From Jan 20, 2016 to June 20, 2016.

Material and Methods:. Patients of both genders between age of 0-6 years with PCG and IOP of 21 mm Hg or more with and without topical anti-glaucoma medication were included in the study. Eyes with complicated or traumatic cataract and previous ocular surgeries were excluded from the study. Sample size was calculated by WHO software for sample size calculation using 77.10 % proportion of decrease in IOP and 95% confidence interval and a 7% margin of error. Diagnosis was confirmed by examination under general anesthesia. All the surgeries were done by same ophthalmologist. 0.4 mg/ml of MMC was applied below the flap for two minutes followed by copious irrigation. Follow up visit was done on 14th post-operative day. EUA was performed 2 months after surgery where the eye was examined for Bleb morphology, leakage, infection or any other complication.

Results: In this study 38 patients undergoing Trabeculectomy with Mitomycin C were followed. Out of 38 patients 24 were male and 14 were female. Average age was 1.49 ± 0.95SD years. Average pre-operative intraocular pressure (IOP) was 29.81 ± 4.80 SD while post-operative IOP was 17.21 ± 3.82 SD.

Conclusion: Intraocular pressure was decreased significantly in patients after Trabeculectomy with Mitomycin C.

Key words: Congenital glaucoma, Trabeculectomy, Mitomycin C.