Comparison between Epiretinal Membrane Component in Proliferative Vitreoretinopathy and Other Fibroproliferative Diseases: A Scoping Review

Doi: 10.36351/pjo.v40i4.1886

Authors

  • Amanda Natalie Wijaya
  • Raihanny Andrea Zahra
  • Anggun Rama Yudantha

DOI:

https://doi.org/10.36351/pjo.v40i4.1886

Abstract

The growth of proliferative vitreoretinopathy epiretinal membrane (PVR-ERM) is a major complication of rhegmatogenous retinal detachment (RRD). Despite surgery, adjunct treatment is necessary to control the aberrant wound healing response that occurs in PVR-ERM to prevent its recurrence. Existing studies on adjunct agents target pathways in the pathogenesis of PVR-ERM. We conducted a scoping review of composition of PVR-ERMs and other fibroproliferative ERMs. After literature search, 12 articles were included into the study. Outcome measured was gene expression, growth factors, extracellular matrix components, and enzymes.Among these studies, 9 compared PVR-ERM with PDR-ERM, 2 compared PVR-ERM with iERM, and 1 compared PVR-ERM with secondary ERM. Higher expression of certain genes or a higher concentration of particular factors can be observed throughout PVR, PDR, iERM, or secondary ERM.TGF-β, MALAT1 gene, and fibronectin are distinct factors that might play a bigger role on the pathogenesis of PVR compared to other fibroproliferative diseases.

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Published

01-10-2024

How to Cite

1.
Wijaya AN, Zahra RA, Yudantha AR. Comparison between Epiretinal Membrane Component in Proliferative Vitreoretinopathy and Other Fibroproliferative Diseases: A Scoping Review: Doi: 10.36351/pjo.v40i4.1886. pak J Ophthalmol [Internet]. 2024 Oct. 1 [cited 2024 Dec. 11];40(4). Available from: https://pjo.org.pk/index.php/pjo/article/view/1886

Issue

Section

Review Articles