Comparison of Fluorometholone 0.1% and Cyclosporine 0.05% in the Treatment of Vernal Keratoconjunctivitis

Doi: 10.36351/pjo.v40i2.1691


  • Ahmed Usman Khalid
  • Umaira Liaqat



Purpose:  To compare the effectiveness of Fluorometholone 0.1% and Cyclosporine 0.05% in the treatment of vernal keratoconjunctivitis.

Study Design:  Quasi experimental study.

Place and Duration of Study:  Hayatabad Medical Complex, Peshawar from December 2020 to June 2021.

Methods:  This study includes 104 patients divided into 2 groups. Patients in Group A were given topical Fluorometholone 0.1% while group B were given topical Cyclosporine 0.05%. Signs and symptoms were graded from scale 0-10 at the start of treatment and then at day 7,14 and 30. Drug was considered effective if the final score was equal to or less than 3 at day 30.

Results:  Mean age of the patients was 9.96±2.722 years in group A and 10.02±2.790years in group B. Mean baseline score was 6.90±0.721 in group A and 5.87±0.768in group B. In group A, 45 (86.5%) patients showed effectiveness while in group B, 36 (69.2%) patients showed effective results. Fluorometholone gave superior results as compared to Cyclosporine in patients with severe disease i.e., baseline score ≥ 6.Systemic allergic associations were noted in44.2% patients in group A and 36.5% patients in group B.

Conclusion:  These findings suggest that Fluorometholone may be a preferable treatment option for vernal keratoconjunctivitis, particularly in cases of more severe disease. However, considerations regarding systemic allergic associations should also be taken into account when making treatment decisions.




How to Cite

Ahmed Usman Khalid, Umaira Liaqat. Comparison of Fluorometholone 0.1% and Cyclosporine 0.05% in the Treatment of Vernal Keratoconjunctivitis: Doi: 10.36351/pjo.v40i2.1691. pak J Ophthalmol [Internet]. 2024 Apr. 1 [cited 2024 Jul. 20];40(2). Available from:



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