Effect of Oral Riboflavin and Direct-sun UV-A on Tumor Necrosis Factor Alpha (TNF-α) Concentrations in Tears of Mild-Moderate Keratoconus Patients

Doi: 10.36351/pjo.v40i1.1690

Authors

  • Reza Aulia Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada – Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Suhardjo Pawiroranu
  • Angela Nurini Agni Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada – Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Indra Tri Mahayana

DOI:

https://doi.org/10.36351/pjo.v40i1.1690

Abstract

Purpose: To determine the role of intra-silicon oil methotrexate injection to prevent Proliferative Vitreoretinopathy.

Study Design:  Quasi experimental Study.

Place and Duration:  Ophthalmology department of Sahiwal Teaching Hospital, Sahiwal from February 2022 to August 2022.

Methods:  Study included patients of either gender, older than 19 years with rhegmatogenous retinal detachment with Proliferative vitreoretinopathy (PVR) grade B or less. There were two groups and each group had fifty-one patients. All patients underwent pars plana vitrectomy and silicon oil tamponade. Group 1 was control group. Group 2 had intravitreal injections of methotrexate 500mg at the end of surgery. We repeated the injections at 1st, 2nd, and 4th week postoperatively.

Results:  There were 56 (54.9%) male and 46 (45.1%) female patients. Postoperatively visual acuity improved in thirty cases (58.82%) in group 1 and in forty-two cases (82.35%) in group 2. Postoperatively PVR developed in 11 (21.57%) patients in group 1 while in group 2 no patient had PVR. Recurrent Retinal detachment occurred in 9 (19.61%) patients in group 1 and 3 (5.88%) patients in group 2. Chi square test demonstrated statistically significant difference in the frequency of development of PVR and re-detachment of retina between two groups, p<0.05.

Conclusion:  Methotrexate is an effective adjuvant used in Pars plana Vitrectomy for rhegmatogenous retinal detachment repair. It prevents Proliferative vitreoretinopathy resulting in better surgical and functional outcome.

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Published

04-12-2023

How to Cite

1.
Aulia R, Suhardjo Pawiroranu, Agni AN, Indra Tri Mahayana. Effect of Oral Riboflavin and Direct-sun UV-A on Tumor Necrosis Factor Alpha (TNF-α) Concentrations in Tears of Mild-Moderate Keratoconus Patients: Doi: 10.36351/pjo.v40i1.1690. pak J Ophthalmol [Internet]. 2023 Dec. 4 [cited 2024 Mar. 5];40(1). Available from: https://pjo.org.pk/index.php/pjo/article/view/1690

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Original Articles