Role of Intrasilicon Oil Methotrexate Injection to Prevent Development of Proliferative Vitreoretinopathy

Doi: 10.36351/pjo.v40i1.1689


  • Ahmad Zeeshan Jamil
  • Muhammad Hannan Jamil
  • Abdullah Muaz
  • Hina Nazir
  • Muhammad Nauraiz Zubair Chawla



Purpose: To determine the role of intra-silicon oil methotrexate injection to prevent Proliferative Vitreoretinopathy.

Study Design:  Quasi experimental Study.

Place and Duration:  Ophthalmology department of Sahiwal Teaching Hospital, Sahiwal from February 2022 to August 2022.

Methods:  Study included patients of either gender, older than 19 years with rhegmatogenous retinal detachment with Proliferative vitreoretinopathy (PVR) grade B or less. There were two groups and each group had fifty-one patients. All patients underwent pars plana vitrectomy and silicon oil tamponade. Group 1 was control group. Group 2 had intravitreal injections of methotrexate 500mg at the end of surgery. We repeated the injections at 1st, 2nd, and 4th week postoperatively.

Results:  There were 56 (54.9%) male and 46 (45.1%) female patients. Postoperatively visual acuity improved in thirty cases (58.82%) in group 1 and in forty-two cases (82.35%) in group 2. Postoperatively PVR developed in 11 (21.57%) patients in group 1 while in group 2 no patient had PVR. Recurrent Retinal detachment occurred in 9 (19.61%) patients in group 1 and 3 (5.88%) patients in group 2. Chi square test demonstrated statistically significant difference in the frequency of development of PVR and re-detachment of retina between two groups, p<0.05.

Conclusion:  Methotrexate is an effective adjuvant used in Pars plana Vitrectomy for rhegmatogenous retinal detachment repair. It prevents Proliferative vitreoretinopathy resulting in better surgical and functional outcome.




How to Cite

Jamil AZ, Muhammad Hannan Jamil, Abdullah Muaz, Hina Nazir, Muhammad Nauraiz Zubair Chawla. Role of Intrasilicon Oil Methotrexate Injection to Prevent Development of Proliferative Vitreoretinopathy: Doi: 10.36351/pjo.v40i1.1689. pak J Ophthalmol [Internet]. 2023 Dec. 4 [cited 2024 Mar. 5];40(1). Available from:



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