Topical Diltiazem Vs. Travoprost in Reducing Intraocular Pressure in Ocular Hypertensive / Glaucomatous Rabbits
Purpose: To demonstrate the Intraocular Pressure (IOP) lowering effect of
topical Diltiazem (calcium channel blocker) in comparison to Travoprost (antiglaucoma
Material and Methods: The study was conducted on 50 healthy rabbits of local
strain, weighing 1500 to 2000 grams. They were kept at the animal house of
Department of Pharmacology, Khyber Medical College Peshawar. Effect of
drugs was studied on both eyes of conscious rabbits. Rabbits were divided into
four groups i.e. A, B, C and D. Rabbits of group A, B and C were made ocular
hypertensive / glaucomatous by injecting weekly sub conjunctival
betamethasone suspension. The iatrogenic glaucoma of group “A” animals were
treated with topical Diltiazem and group B with topical Travoprost drops. Group
C served as ocular hypertensive control. It received only artificial tears during the
research period. Group D rabbits were used as normotensive control. They were
neither induced for glaucoma nor did they receive any treatment during the
Results: Our study revealed that there was 19% (5.00 + 0.25 mm Hg) drop in
Intra Ocular Pressure with topical Diltiazem. Its onset of action was quick and
duration of action prolonged. Whereas topical Travoprost reduced IOP by 15%
(4.00 + 0.25 mm Hg). Topical Diltiazem was found consistent in its intraocular
pressure lowering effect as compared to Travoprost.
Conclusion: Topical Diltiazem can be used as an alternative anti glaucoma drug
in future if found safe in human trials.
Key words: Glaucoma, Ocular hypertension, Betamethasone suspension,
Calcium Channel Blockers (CCB), Intraocular Pressure (IOP).