Glaucoma and Ocular Hypertension in Pseudoexfoliation Syndrome

  • Azfar Ahmed Mirza, Noor Bakht Nizamani, Mariya Nazish Memon, Sajjad Ali Surhio, Khalid I. Talpur


Purpose: To assess the frequency of glaucoma and ocular hypertension in
pseudoexfoliation syndrome.
Material and Methods: This study was conducted in the Department of
Ophthalmology, Liaquat University Eye Hospital, Hyderabad, Pakistan from June
2011 to December 2011. Hundred confirmed cases of pseudoexfoliation
syndrome (PXS) were included in the study by non-probability convenience
sampling. Tonometry, gonioscopy, ophthalmoscopy and visual field analysis
were carried out to determine glaucoma. Data was collected by specially
designed proforma and analyzed by using Statistical Program for Social
Sciences (SPSS, version 16.0 for Windows). The frequencies and percentage
were recorded and any association with predisposing factors was statistically
analyzed on chi square test. P-value of <0.001 was considered significant with a
confidence interval (CI) of 95%.
Results: Out of the 100 PXS patients, 16% patients were diagnosed with
pseudoexfoliation glaucoma (PXG) (CI 95%): 12% with open angle glaucoma
and 4% narrow angle glaucoma. Ocular hypertension without glaucomatous
changes was detected in 9% (CI 95%) of the patients (P <0.001). PXG was more
common after 50 years of age while ocular hypertension occurred earlier i.e. 40
years. Gender (P=0.45), locality (P=0.725) and family history of glaucoma
(P=0.95) were statistically insignificant risk factors for development of glaucoma
in PXS patients. Increased age, intraocular pressure and cup-disc ratio (16%)
were significant risk factors for development of PXG (P <0.001 CI 95%).
Conclusion: Increasing age, intraocular pressure and cup disc ratio are
significant risk factors for development of glaucoma in PXS. It is recommended
that patients over 50 years should be actively examined for glaucoma particularly
those with PXS.
Keywords: Pseudoexfoliation syndrome, Glaucoma, Ocular Hypertension

How to Cite
Khalid I. Talpur AAMNBN. Glaucoma and Ocular Hypertension in Pseudoexfoliation Syndrome. pjo [Internet]. 30Jun.2015 [cited 5Dec.2020];31(2). Available from:
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