Comparison of intravitreal Diclofenac-Sodium Versus intravitreal Triamcinolone in diabetic Macular Edema

Doi: 10.36351/pjo.v38i4.1365

Authors

  • Adnan Ahmad Nowshera Medical College, Nowshera
  • Mubashir Rehman Nowshera Medical College, Nowshera
  • Hamid Rehman Bannu Medical College, Bannu

DOI:

https://doi.org/10.36351/pjo.v38i4.1365

Abstract

Purpose:  To compare the effectiveness of intra-vitreal Diclofenac-Sodium (IV-D) versus intra-vitreal Triamcinolone Acetonide (IV-T) in the treatment of diabetic macular edema (DME).

Study Design:  Quasi experimental study.

Place and Duration of Study:  Qazi Hussain Medical Complex, Nowshera from October 2020 to April 2021.

Methods:  We recruited 40 eyes with diabetic macular edema (DME). Two groups were made. One group was assigned to 4 mg/0.1 cc of IV-T and the other group received 0.5 mg/0.1 cc of IV-D. There were 20 eyes in each group. Pre and post-opbest corrected visual acuity (BCVA), intra-ocular pressure (IOP), and central subfield thickness of macula (CSFT) were documented and analysed in both groups. The patients were followed up for 3 months after injection.

Results:  Both treatment arms displayed marked decrease in CSFT (IV-T with p = 0.03 and IV-D with p = 0.02), but the difference between groups were not statistically significant. Statistically significant improvement in BCVA was seen in IV-T from the baseline (p = 0.04). However, difference between the two groups regarding BCVA was not statistically significant. Transient increase in IOP occurred in 20% of IV-T. In IV-D reduction in IOP was observed that achieved the level of statistical significance (p = 0.03).

Conclusion:  IV-D was better in management of DME in terms of IOP after intravitreal injection and IV-T showed superior results in BCVA. However, both IV-T and IV-D showed similar efficacy in reduction of CSFT.

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Published

30-09-2022

How to Cite

1.
Ahmad A, Rehman M, Rehman H. Comparison of intravitreal Diclofenac-Sodium Versus intravitreal Triamcinolone in diabetic Macular Edema: Doi: 10.36351/pjo.v38i4.1365. pak J Ophthalmol [Internet]. 2022 Sep. 30 [cited 2022 Dec. 6];38(4). Available from: https://pjo.org.pk/index.php/pjo/article/view/1365

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Original Articles