Effects of Intravitreal Aflibercept in Patients with Central Serous Chorioretinopathy

Doi:10.36351/pjo.v36i4.1098

  • Ali Afzal Bodla Multan Medical and Dental College, Multan and Bodla Eye Care
  • Muhammad Afzal Bodla Department of Ophthalmology, Multan Medical and Dental College, Multan
  • Syeda Minahil Kazmi Department of Ophthalmology, Multan Medical and Dental College, Multan
  • Ayema Moazzam Department of Ophthalmology, Multan Medical and Dental College, Multan
Keywords: Central retinal thickness, Central Serous chorioretinopathy, Aflibercept.

Abstract

Purpose:  The purpose of this study is to assess the efficacy of intravitreal injection of Afliberceptin patients with chronic central serous chorioretinopathy (CSCR).

Study Design:  Interventional case series.

Place and Duration of Study: Multan Medical and Dental Centre and Bodla Eye Care from February 2019 to February 2020.

Methods:  This study was conducted on fifteen eyes with sub-acute to chronic central serous chorioretinopathy. All patients who had undergone previous treatment with laser photocoagulation, intravitreal triamcinolone, or bevacizumab in past 3 months, history of glaucoma (intraocular pressure > 21 mmHg), patients who lost to follow-up, and those with previously vitrectomized eyes were excluded. Patients were treated with a single dose of intravitreal injection of Aflibercept (0.5 mg/0.05 ml). Visual acuity with Log MAR chart and central retinal thickness were studied before and after the injection.

Results:  The mean age of the patients was 30.46 years ± 9 years. After one month of intravitreal Aflibercept injection, visual acuity improved from 0.32 Log MAR to 0.173 log MAR and at 3 months (the last follow-up) it was 0.206 Log MAR. Central retinal thickness (CRT) improved from 437 ± 82 µm (at the time of presentation) to 349 ± 67 µm at 1 month post injection. At the last follow-up the mean CRT decreased to 309 ± 121 µm. Except for two eyes, all eyes showed visual improvement. These two eyes had a higher CRT as compared to other participants.

Conclusion:  Intravitreal injection of Afliberceptis effective in improving BCVA and decreasing the central retinal thickness in patients central serous chorioretinopathy.

Key Words:  Central retinal thickness, Central Serous chorioretinopathy, Aflibercept.

Published
2020-09-02
How to Cite
1.
Bodla A, Afzal Bodla M, Minahil Kazmi S, Moazzam A. Effects of Intravitreal Aflibercept in Patients with Central Serous Chorioretinopathy. pjo [Internet]. 2Sep.2020 [cited 19Oct.2020];36(4). Available from: https://pjo.org.pk/index.php/pjo/article/view/1098
Section
Original Articles