FREQUENCY OF HELICOBACTER PYLORI IN PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA

  • Zeeshan Khan OOZEERKHAN Gulab Devi Teaching Hospital
Keywords: Ophthalmology, Optic Neuropathy, Open angle Glaucoma, H.Pylori

Abstract

BACKGROUND

Primary Open Angle Glaucoma (POAG) is one of the most common causes of irreversible pathological visual loss. Helicobacter pylori (H.pylori) is a rod that colonizes the gastric mucosa and has strong associations with diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Frequency of H.pylori in patients of POAG has not been reported in Pakistan.

OBJECTIVE

This study is to find out the frequency of H.pylori antibody in the serum of people with established POAG.

Study Design: Cross Sectional Survey

Place of study: LRBT Free Eye Hospital, Lahore.

Duration: 6 months

MATERIALS AND METHODS

Consecutive sampling was used and informed consent and demographic information of patients was taken from 100 patients. 3ml of venous blood processed through the chemiluminescent enzyme immunoassay of the Immulite 2000 Systems Analyzers H.pylori Ig G detection kit. The Quantitative variables such as age were presented as mean and standard deviation while qualitative variables such as gender and H.pylori status (positive or negative) were expressed as frequency and percentage.

RESULTS

Patients’ mean age was 50.45 ± 6.16 years. There were 49 (49%) male and 51 (51%) female patients. The mean antibody level of patients was 3.80 ± 2.57 with range of 9.39. The minimum and maximum antibody level were 0.07 and 9.46 respectively. 75 (75%) patients were shown to be positive with H.pylori.

CONCLUSION

The study shows high frequency of H.pylori antibody in patients with Open Angle Glaucoma. Importance of this serious health concern should be investigated and eradicated at all stages of POAG.

 

References

1. Kanski JJ, Glaucoma BB, Gabbedy R, Cook L. Clinical Ophthalmology A Systemic Approach. 7th Ed. China: Elsevier; 2011: 380.
2. Kumar V, Abbass AK, Fausto N, Aster J. Robbins and Cotran: Pathologic Basis of Diseases. 8h Ed. India: Elsevier; 2010: 776-787.
3. Deshpande N, Lalitha P, Krishna das SR, Jethani J, Pillai M, Robin A, Karthik. Helicobacter pylori IgG Antibodies in Aqueous Humor and Serum of Subjects with Primary Open Angle and Pseudo-exfoliation Glaucoma in a South Indian population. J Glaucoma. 2008; 17(8): 605-10.
4. Zaidi M, Jilani F, Gupta Y, Umair S, Gupta M. Association between helicobacter pylori and open angle glaucoma: current perspective. Nepalese Journal of Ophthalmology. 2009;1(2):129-35.
5. Razeghinejad MR, Kamali-Sarvestani E, Farvardin M, Pourhabibi A. Aqueous levels of anti-Helicobacter pylori IgG antibody in patients with primary open angle and pseudoexfoliation glaucoma. Iran J Immunol. 2006;3:86-90.
6. Hong Y, Zhang C, Duan L, Wang W. Relationship between Helicobacter pylori infection and open angle glaucoma in China. Asian J Ophthalmol. 2007;9:205-8.
7. Kountouras J, Mylopoulos N, Chatzopoulos D, Zavos C, Boura P, Konstas AG, et al. Eradication of Helicobacter pylori may be beneficial in the management of chronic open-angle glaucoma. Archives of internal medicine. 2002;162(11):1237-44.
08. Kwon YH, Fingert JH, Kuehn MH, Alward WL. Primary open-angle glaucoma. New England Journal of Medicine. 2009;360(11):1113-24.
09. Tsolaki F, Gogaki E, Sakkias F, Skatharoudi C, Lopatatzidi C, Tsoulopoulos V, et al. Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? Clin Ophthalmol. 2012;6:45-7.
10. Tsolaki F, Gogaki E, Tiganita S, Skatharoudi C, Lopatatzidi C, Topouzis F, et al. Alzheimer’s disease and primary open-angle glaucoma: is there a connection? Clinical ophthalmology (Auckland, NZ). 2011;5:887-90.
11. Selgrad M, Bornschein J, Rokkas T, Malfertheiner P. Clinical aspects of gastric cancer and Helicobacter pylori–screening, prevention, and treatment. Helicobacter. 2010;15(s1):40-5.
12. Goh KL, Chan WK, Shiota S, Yamaoka Y. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter. 2011;16(s1):1-9.
13. Galloway PH, Warner SJ, Morshed MG, Mikelberg FS. Helicobacter pylori infection and the risk for open-angle glaucoma. Ophthalmology. 2003;110(5):922-5.
14. Kountouras J, Mylopoulos N, Boura P, Bessas C, Chatzopoulos D, Venizelos J, et al. Relationship between Helicobacter pylori infection and glaucoma. Ophthalmology. 2001;108(3):599-604.
15. Kountouras J, Zavos C, Chatzopoulos D. Primary open-angle glaucoma: pathophysiology and treatment. The Lancet. 2004;364(9442):1311-2.
16. Hayreh SS, Jonas JB. Optic disc morphology after arteritic anterior ischemic optic neuropathy. Ophthalmology. 2001;108(9):1586-94.
17. Haefliger IO, Dettmann E, Liu R, Meyer P, Prünte C, Messerli J, et al. Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma. Survey of ophthalmology. 1999;43:S51-S8.
18. Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary open-angle glaucoma: the Baltimore Eye Survey. Jama. 1991;266(3):369-74.
19. Dielemans I, Vingerling JR, Wolfs RC, Hofman A, Grobbee DE, de Jong PT. The prevalence of primary open-angle glaucoma in a population-based study in the Netherlands: the Rotterdam Study. Ophthalmology. 1994;101(11):1851-5.
20. Zavos C, Kountouras J, Sakkias G, Venizelos I, Deretzi G, Arapoglou S. Histological presence of Helicobacter pylori bacteria in the trabeculum and iris of patients with primary open-angle glaucoma. Ophthalmic research. 2011;47(3):150-6.
21. Parsonnet J.The incidence of Helicobacter pylori infection. Aliment.
Pharmacol. Ther. 1995;9(Suppl.2):45-51.
Published
2019-12-19
Section
Review Articles