Vitreo-macular Interface Abnormalities in Diabetic and Non-Diabetic Patients Using Optical Coherence Tomography
Purpose: To study the frequency of vitreomacular interface abnormalities (VIAs) in diabetic and non-diabetic
patients presenting in a tertiary care hospital.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Jinnah hospital, Lahore from May 2013 to June 2016.
Methods: The frequency of vitreomacular interface abnormalities (VIAs) was assessed among 278 patients, who
presented in outpatient department of our hospital. Patients were categorized into diabetic and non-diabetic
groups on the basis of hemoglobinHbA1c. Patients with altered macular reflex on slit lamp examination underwent
spectral domain (SD) optical coherence tomography (OCT) of macula to determine VIAs.
Results: There were 278 patients in the study with mean age 59.7 ± 11.7(range: 40 – 65) years and male to
female ratio of 1:1.06. Prevalence of VIAs was observed to be higher among diabetic patients than non-diabetics
in all age groups (p-value < 0.05). Overall frequency of different VIAs was found to be 10.7% for epiretinal
membrane, 6.4% for posterior vitreous detachment, 6.1% for macular edema/macular cyst, 4.3% for
vitreomacular traction, 1.8% for full thickness macular holes and 0.71% for partial thickness macular holes.
Macular edema/macular cystwas the most common. VIA was more commonly observed in diabetic patients
(17.2%). Except for ERM, all lesions of VIAs were significantly more prevalent in females as compared to males.
Conclusion: VIAs are found in significantly larger number in diabetics compared to non-diabetic patients.
Female gender with advancing age is associated with a higher frequency of VIAs.