TY - JOUR AU - Z.A Qazi, Muhammad Younis Tahir, Rafay Amin Baig, Khalid Masood Ashraf, Moazam babar, PY - 2008/12/31 Y2 - 2024/03/28 TI - Comparative Study of Endothelial Cell Loss after Phacoemulsification by Using 2% Hydroxypropyl Methylcellulose (HPMC) Versus 2.3% Sodium Hyaluronate (Healon 5) JF - Pakistan Journal of Ophthalmology JA - pak J Ophthalmol VL - 24 IS - 4 SE - Review Articles DO - 10.36351/pjo.v24i4.676 UR - https://pjo.org.pk/index.php/pjo/article/view/676 SP - AB - <p><strong>Purpose</strong>: To compare the protective effect of Healon 5 and HPMC on corneal&nbsp;endothelium during phacoemulsification.</p><p><strong>Material and Methods</strong>: All eyes scheduled to have phacoemulsification surgery&nbsp;by single surgeon at same centre were selected. First group was operated<br>while using HPMC as viscoelastic agent and second group of eyes underwent&nbsp;identical surgery while using Healon 5 as viscoelastic agent. Patients were&nbsp;followed up at 24 hours, one week, one month, and 3 months after surgery for&nbsp;corneal endothelial cell loss by using specular microscope.&nbsp;</p><p><strong>Results</strong>: Fifty eyes underwent surgery equally divided in two groups. In first&nbsp;group HPMC was used. The mean loss of corneal endothelial cells at 3&nbsp;months was 8.67 %( 6.57%-13.61%). In second group Healon 5 was used&nbsp;during surgery and the mean loss of corneal endothelial cells at 3 months was&nbsp;8.05 %( 6.58%-10.94%).<br><strong>Conclusions</strong>: The rate of corneal endothelial cell loss in patients undergoing&nbsp;phacoemulsification cataract surgery with HPMC or Healon 5 does not vary&nbsp;much although Healon 5 works better if there is advanced nuclear sclerosis.&nbsp;But in routine cases use of HPMC is a safe and cost effective.</p> ER -