@article{Ahmad_Rehman_Rehman_2022, title={Comparison of intravitreal Diclofenac-Sodium Versus intravitreal Triamcinolone in diabetic Macular Edema: Doi: 10.36351/pjo.v38i4.1365}, volume={38}, url={https://pjo.org.pk/index.php/pjo/article/view/1365}, DOI={10.36351/pjo.v38i4.1365}, abstractNote={<p><strong>Purpose:</strong>  To compare the effectiveness of intra-vitreal Diclofenac-Sodium (IV-D) versus intra-vitreal Triamcinolone Acetonide (IV-T) in the treatment of diabetic macular edema (DME).</p> <p><strong>Study Design:</strong>  Quasi experimental study.</p> <p><strong>Place and Duration of Study:</strong>  Qazi Hussain Medical Complex, Nowshera from October 2020 to April 2021.</p> <p><strong>Methods:</strong>  We recruited 40 eyes with diabetic macular edema (DME). Two groups were made. One group was assigned to 4 mg/0.1 cc of IV-T and the other group received 0.5 mg/0.1 cc of IV-D. There were 20 eyes in each group. Pre and post-opbest corrected visual acuity (BCVA), intra-ocular pressure (IOP), and central subfield thickness of macula (CSFT) were documented and analysed in both groups. The patients were followed up for 3 months after injection.</p> <p><strong>Results:</strong>  Both treatment arms displayed marked decrease in CSFT (IV-T with <em>p </em>= 0.03 and IV-D with <em>p </em>= 0.02), but the difference between groups were not statistically significant. Statistically significant improvement in BCVA was seen in IV-T from the baseline (<em>p</em> = 0.04). However, difference between the two groups regarding BCVA was not statistically significant. Transient increase in IOP occurred in 20% of IV-T. In IV-D reduction in IOP was observed that achieved the level of statistical significance (<em>p</em> = 0.03).</p> <p><strong>Conclusion:</strong>  IV-D was better in management of DME in terms of IOP after intravitreal injection and IV-T showed superior results in BCVA. However, both IV-T and IV-D showed similar efficacy in reduction of CSFT.</p>}, number={4}, journal={Pakistan Journal of Ophthalmology}, author={Ahmad, Adnan and Rehman, Mubashir and Rehman, Hamid}, year={2022}, month={Sep.} }