TY - JOUR AU - Imtiaz, Hafiza Sadia AU - Qayyum, Irfan AU - Iqbal, Usama AU - Ali, Farhan AU - Sharjeel, Muhammad PY - 2020/01/23 Y2 - 2024/03/29 TI - The Efficacy of 0.03% Dermatological Tacrolimus Ointment for Refractory Vernal Keratoconjunctivitis. JF - Pakistan Journal of Ophthalmology JA - pak J Ophthalmol VL - 35 IS - 4 SE - Original Articles DO - 10.36351/pjo.v35i4.872 UR - https://pjo.org.pk/index.php/pjo/article/view/872 SP - 229-234 AB - <p>&nbsp;</p><p><strong>Purpose:</strong> To determine the efficacy of 0.03% dermatological tacrolimus ointment in patients with refractory vernal keratoconjunctivitis</p><p><strong>Study Design: </strong>Quasi-experimental study</p><p><strong>Study Place and Duration:</strong> Eye Department, DHQ-Teaching Hospital, Gujranwala, Pakistan from April 2018 to March 2019</p><p><strong>Material and Methods: </strong>After approval from hospital ethical committee and obtaining written informed consent from each patient/guardian, patients of either gender between 4-16 years of age with VKC not responding to conventional treatment for more than 8 weeks or having steroid-induced complications were included in this study. Dermatological tacrolimus ointment 0.03% started to be placed in inferior fornix in BD frequency along with topical lubricants. Patients were followed up on a regular schedule. Individual symptoms score was assessed from the questionnaire and signs score from observer’s clinical assessment. Data were analyzed using SPSS v23.0. P-value &lt;0.05 was considered as statistically significant.</p><p><strong>Results: </strong>40 eyes of 20 patients were included in this study. Out of which 4(20%) were female and 16 were male (80%). Mean baseline score for clinical symptoms was 6.65±1.81 that reduced to 1.65±0.81 after 12 weeks treatment course of tacrolimus with a significant p-value of 0.006 (p&lt;0.05). Mean baseline score for clinical signs was 5.9±1.59 that improved to 1.80±0.83 after 12 weeks treatment course with a statistically significant p-value of 0.003 (p&lt;0.05).</p><p><strong>Conclusions: </strong>In conclusion, topical tacrolimus dermatological ointment 0.03% is highly effective in refractory VKC and can be safely used as an alternative in VKC patients who are steroid-responders.</p> ER -